chapter  2
Aetiology of head and neck cancer
ByPablo H. Montero, Snehal G. Patel, Ian Ganly
Pages 10

SQUAMOUS MALIGNANT TUMOURS Squamous cell carcinoma of the head and neck encompasses cancer of the oral cavity, oropharynx, larynx and hypopharynx, nasopharynx, nasal cavity and paranasal sinuses. The two most important factors in the aetiology of head and neck cancer are tobacco and alcohol.5 There is a synergistic interaction between these two agents that is multiplicative for the mouth, additive for larynx and between additive and multiplicative for oesophagus.6