chapter  39
Transcription Factors as Activators and Repressors of Gene Transcription: NF-KB and Glucocorticoid Receptors
ByIan M. Adcock, Robert Newton
Pages 18

Extracellular signals, such as inflammatory stimuli, are generally communicated to the interior of the cell via receptors on the cell surface. Ligand-receptor interaction initiates various intracellular signaling cascades (signal transduction) that result in activation of specific deoxyribonucleic acid (DNA) binding proteins or transcription factors (2,3). Binding of these factors to specific recognition sequences in the control regions (promoters) of target genes is communicated to the basal transcription machinery causing activation of ribonucleic acid (RNA) polymerase IT-dependent transcription.