ABSTRACT
Introduction
Reactive Oxygen Species, Antioxidant Defenses, and Oxidative Stress-Mediated Cell Death
Reactive Oxygen Species and Antioxidant Defenses
Oxidative Stress: Necrosis and Apoptosis
Excitotoxicity and Oxidative Stress
Role of Oxidative Stress in Various Neurological Diseases
Amyotrophic Lateral Sclerosis
Parkinson’s Disease
Alzheimer’s Disease
Glutathione in the Nervous System
Glutathione, Oxidative Stress, and Mitochondrial Damage
Glutathione Modulation in Amyotrophic Lateral Sclerosis
Glutathione and Parkinson’s Disease
Glutathione and Alzheimer’s Disease
A Working Model of GSH Depletion and Neurological Disease
Therapeutic Approaches to Neurological Diseases
Summary
References
