ABSTRACT
Introduction
Glutathione in the CNS
Glutamate Receptors
Glutathione and Glutathione Derivatives as Modulators of Glutamatergic Neurotransmission
Glutathione as a Peptide Ligand of Ionotropic Glutamate Receptors
Binding of Glutamate
Binding of AMPA and Kainate
Binding of NMDA Receptor Ligands
Glutathione as a Redox Modulator of NMDA Receptors
Indirect Modulation of NMDA Receptor Activation via Regulation of Ion Channels
Interaction with the Release of Glutamate
Interaction with the Uptake of Glutamate
Interactions with the Neuronal Influx and Intraneuronal Levels of Ca2+
Interactions with the Ca2+-Dependent Evoked Release of Other Neurotransmitters
Modulation of the Glutamate-Evoked Release of GABA in the Hippocampus
Modulation of the Glutamate-Evoked Release of Dopamine in the Striatum
Modulation of the K+-Evoked Release of Dopamine in the Striatum
Glutathione: Neurotransmitter or Neuromodulator?
The Role of Glutathione in the Regulation of Physiological Processes in the CNS
New Aspects of Neuroprotection by Glutathione
Glutamate Neurotoxicity and Neurological Diseases
Glutathione and GABA Release in Pathological States
Glutathione and Striatal Dopamine Release: Implications in Extrapyramidal Neurodegenerative Diseases
Glutathione and Spreading Depolarization
Conclusions and Perspectives
References
