chapter  8
Mechanism of RNA Synthesis by a Viral RNA-Dependent RNA Polymerase
ByKailayapillai Sivakumaran, Jin-Hua Sun, C. Cheng Kao
Pages 28

Although RNA replication is of fundamental importance for pathogenesis in many RNA viruses, the mechanism remains poorly understood. The RNA-dependent RNA polymerase (RdRp) complex plays a central role in the replication process, but few RdRps that direct this process have been characterized at the biochemical level. Thus, structural and functional studies of RdRps have lagged significantly behind those of other DNA and RNA polymerases. The objective of this chapter is to review some of the current progress made in our laboratory in elucidating the mechanism of RNA replication.