Design and Synthesis of Thiaolidinone-Based Triazines Derivatives as a New Potential Anti-Inflammatory and Anti-Microbial Agent

A frequent approach to synthesize a series of 3-(4,6-dichloro-1,3,5-triazin-2-yl)-2-phenylthiazolidin-4-one was developed by applying an efficient multi-component reaction (MCR). Also, the synthesized compounds were tested for their antimicrobial activity, anti-inflammatory (TNF-and IL-6) activity. The most admirable results were observed with the substituted phenylthiazolidin-4-one triazine analogs and it could be a potential starting point to develop innovative lead compounds fight against bacteria and fungi. The presence of lipophilic -Cl and -F at 5^th position tolerates the procytokine activity All synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, mass, and elemental analysis.