chapter  4
22 Pages

- Targeted Muscle Reinnervation as a Strategy for Neuroma Prevention

ByJason H. Ko, Peter S. Kim, Douglas G. Smith

When a peripheral nerve is transected, a bulbous swelling, or neuroma, will develop at the severed end of the nerve (Figure 4.1). Neuromas consist of disorganized, chaotic axons encased in significant scar and fibrous tissue. They are frequently sensitive to pressure and other forms of mechanical irritation, causing a focal pain that is often difficult to treat. By providing a distal muscle target for the proximal transected axons to grow into, targeted muscle reinnervation (TMR) may represent a novel technique for the prevention and treatment of neuromas. In this chapter, we will discuss the pathophysiology

CONTENTS

4.0 Introduction ..................................................................................................45 4.1 Neuroma Pathophysiology .........................................................................46