ABSTRACT
The concept of ‘neuroprotection’ can be traced to the use of cold by ancient Greek physicians to treat injuries and stroke – which they believed were related to excess body heat (Hoff, 1986). In fact, the practice of these ancient physicians may not have been misplaced: contemporary studies show a high incidence of fever in the first 72 hours after TBI and the presence of fever is associated with poorer outcome (Cairns and Andrews, 2002).
