ABSTRACT

Introduction 211 Physicochemical properties of local anaesthetics 211 Pharmacokinetics 212 Pharmacodynamics 216

Toxicity of local anaesthetics 217 Adjuncts to local anaesthetics 219 References 222

This chapter will explore the pharmacology of local anaesthetic agents with the emphasis on clinical relevance. The differences in pharmacokinetics, pharmacodynamics, clinical activity and toxicity between adults and children will be explored. The pharmacology of adjuvant drugs commonly used in paediatric anaesthesia will be discussed.