chapter  1
Dosimetric Principles of Targeted Radiotherapy
WithJoseph A. O’Donoghue
Pages 20

For disseminated or diffuse malignant disease a systemic approach to treatment is required. To achieve selective and systemic therapy simultaneously has been a longstanding objective of cancer research (1). This goal cannot be achieved by physical means and requires exploitation of the biological differences between cancerous and noncancerous cells.