ABSTRACT
This chapter explores how one of the industry’s major players, Extract Technology, an equipment supplier, has significantly standardized a detailed assessment program for the purpose of project-to-project consistency—a laudable but often elusive goal. Decisions about containment approaches within pharmaceutical companies are generally made on the basis of experience: Industrial hygienists and containment engineers are aware of myriad factors that affect emissions—where along their production lines they’ll need to button up or where local exhaust is adequate to capture emissions at low levels or emissions of less hazardous products. The operator-to-material interface cannot be precisely quantified, but certain commonsense evaluations can be made: For operations performed on a monthly schedule, consider the lower end of the containment strategy selections.
