chapter  4
25 Pages

Effect of Individual Particle Characteristics on Airborne Emissions

WithChetan P. Pujara, Dane O. Kildsig

This chapter presents the effects of powder parameters on dustiness of both pharmaceutical and nonpharmaceutical materials. Powders and granulated solids are used throughout the pharmaceutical industry. The handling of these materials generates airborne dust that may affect worker health and safety, cause a nuisance and/or result in product loss. The dust is usually collected on the filter using a suction pump operating at a fixed flow rate. Particle size governs the generation of airborne particles to a large extent and is the major factor governing the motion of particles in a fluid medium. Workers in the pharmaceutical industry may also be exposed to compounds designed to produce extreme pharmacological effects. Workers suffered with airborne contact urticaria due to sodium benzoate in a pharmaceutical manufacturing plant.