ABSTRACT
Cell adhesion plays an important role in cellular physiological functions (such as cell growth, differentiation and motility) and in integration of implantable biomedical devices to cells and tissues. A complete understanding of cell adhesion to materials with different textures is essential to promote integration in tissues and to minimize scar tissue formation. Moreover, the development of tissue-engineering strategies needs also to design biointerfaces between cells and biomaterials to match the anatomy and physiology of the host tissue and to meet the biochemical and biophysical requirements of specific cell types. To do so requires the control of topographical, chemical and mechanical surface properties at length scales on a par
with the size of cells [1]. This justifies the publication of several reviews on this subject in the last ten years in the field of musculo-skeletal tissues [2-4]. In this paper, our objective is to sum up the latest developments in the field by focusing again our attention on interactions between cells and material surfaces.
