ABSTRACT

Contents 12.1 Introduction to Chitosan ........................................................................ 151

12.1.1 Sources and Physicochemical Properties ................................... 151 12.1.2 Biological Properties ................................................................... 153 12.1.3 Toxicity ........................................................................................154

12.2 Body Weight Management of Chitosan ................................................. 155 12.2.1 Binding of Fats ............................................................................156 12.2.2 Immobilization of Bile Salts ........................................................ 157 12.2.3 Suppression of Appetite .............................................................. 157 12.2.4 Genetic Complications ................................................................ 157 12.2.5 In Vitro Trials ..............................................................................158 12.2.6 Animal Trials ...............................................................................158 12.2.7 Clinical Trials ............................................................................... 159

12.3 Complications of Chitosan ..................................................................... 159 12.3.1 Gastrointestinal Disorders .......................................................... 159 12.3.2 Interaction with Lipid-Soluble Vitamins and Minerals .............. 159 12.3.3 Allergic Reaction to Shellfish-Derived Chitosan ........................162

12.4 Chitosan Modification ............................................................................162 12.5 Future of Chitosan as Dietary Nutraceuticals .......................................164 References .......................................................................................................164