ABSTRACT

This chapter provides the background to the DepotOne Needle, a device that can aid the injection of complex formulations such as viscous materials, pastes, gels, and particulates. DepotOne is a family of two-part hypodermic needles designed by Imprint. The technology is applicable to many therapeutic formulations and is currently being used in clinical trials for therapeutics formulated as suspensions, thick pastes and pegylated proteins.