ABSTRACT
Pathophysiology Hypertrophic obstructive cardiomyopathy (HOCM) is a congenital, sometimes hereditary, defect of the amino acid sequence, which can manifest itself by inappropriate hypertrophy of the myocardium, often involving the septum more than the rest of the heart to a varying degree. Histologically, the myocardial cells are abnormal with myocardial disarray and short, broad myocardial cells. Functionally, there is good systolic but impaired diastolic function due to poor myocardial relaxation. Additional hemodynamic problems include outflow tract obstruction (usually involving the left more than the right, but it could involve both sides), mitral regurgitation, and coronary artery compression due to myocardial bridging.
