chapter  13
A Self-Inactivating Retrovector Incorporating the IL-2 Promoter for Activation-Induced Transgene Expression in Genetically Engineered T-Cells
Pages 19

Background T-cells have several features that render them attractive target cells for cell and gene therapy applications. In addition to their diverse and critical role in the immune system, T-cells are readily available from human peripheral blood, they can be easily isolated, activated, expanded to large numbers in vitro, and reinfused with a potential to circulate for a long time in vivo. Indeed, T-cells have been successfully utilized for adoptive immunotherapy of cancer, viral infections, and autoimmune diseases.