chapter  12
20 Pages

Raft-dependent Endocytosis of Autocrine Motility Factor/Phosphoglucose Isomerase

Autocrine motility factor/phosphoglucose isomerase (AMF/PGI) is the extracellular ligand for the gp78/AMFR receptor over-expressed in a variety of human cancers. We showed previously that raft-dependent internalization of AMF/PGI is elevated in metastatic MDA-435 cells, but not metastatic, caveolin-1-expressing MDA-231 cells, relative to non-metastatic MCF7, and dysplastic MCF10A cells suggesting that it might represent a tumor cell-specific endocytic pathway.