chapter  17
16 Pages

Cationic Nanoparticles for Delivery of Amphotericin B

ByDbora B. Vieira, Ana M. Carmona-Ribeiro

Particulate systems are well known to be able to deliver drugs with high efficiency and fewer adverse side effects, possibly by endocytosis of the drug carriers. On the other hand, cationic compounds and assemblies exhibit a general antimicrobial action. In this work, cationic nanoparticles built from drug, cationic lipid and polyelectrolytes are shown to be excellent and active carriers of amphotericin B (AmB) against Candida albicans.