chapter  7
34 Pages

^#.^t7: Chromatographic Analysis of Chiral Drugs

Chirality of pharmaceutical products drew an immense concern of clinicians, pharmaceutical industries, and drug regulatory authorities, at rst, in the 1960s, when the administration of the racemic sedative drug thalidomide to pregnant women resulted in thousands of seriously crippled babies with underdeveloped limbs. Later, it was observed that the (R)-enantiomer of the drug

7.1 Introduction ............................................................................................................................97 7.2 Approaches for Enantioseparation ..........................................................................................98 7.3 Various Steps in TLC Enantioseparation ...............................................................................99