chapter  12
32 Pages

Detection and Identication in TLC Drug Analysis

Thin-layer chromatography (TLC), among other chromatographic and electrophoretic techniques, is an important tool in the analysis of drugs. It is used to quantify active principles or degradation products in pharmaceutical formulations or biological uids, to detect adulterations, or in the development of new active principles. One of the TLC advantages is the possibility of using different detection

12.1 Introduction .......................................................................................................................... 193 12.2 Physical Methods of Detection and Identication ................................................................ 195

12.2.1 TLC with Spectrophotometric Detection (TLC-UV/Vis, TLC-FLD, TLC-DAD) ...195 12.2.2 TLC-MS ................................................................................................................... 196 12.2.3 Other Physical Detection and Identication Modes .................................................200