chapter  22
12 Pages

^#.^t22: TLC of Antiepileptics

Epilepsy is one of the most frequent neurological disorders, both in children and adults. About 0.5%–1% of the general population suffer from epilepsy, which means that about 50 million people in the world are affected. Epilepsy treatment is based on pharmacological therapy. Antiepileptic drugs (AEDs) have different mechanisms of action. The most important in inhibiting seizures are the compounds that block sodium and calcium channels and enhance the GABA-ergic neurotransmission. The antiepileptic drugs presented in this chapter belong to different classes including urea derivatives, iminostilbenes, imides, sulfonamides, GABA analogues, and some miscellaneous drugs (Figure 22.1). The aim of this review is the presentation of published work on the TLC analysis of AEDs in bulk, pharmaceutical formulations, and in biological material.