chapter  30
22 Pages

^#.^t30: TLC of Spasmolytics

Spasmolytics are the group of drugs commonly classied as anticholinergics or antiparasympathetics (parasympatholytics). More precisely, however, they are termed as antimuscarinic agents since they antagonize the muscarine-like actions of acetylcholine and other choline esters. The nerve bers of the parasympathetic system are responsible for the involuntary movements of smooth muscles present in the gastrointestinal tract, urinary tract, lungs, etc. Pharmacologically, spasmolytics are divided into three groups: tropane alkaloids and their semisynthetic analogues, anticholinergic agents with different structure, and musculotropic spasmolytics, which are selective inhibitors of phosphodiesterase 4 and have no anticholinergic effects.