chapter  43
26 Pages

^#.^t43: TLC of Sulfonamides

Sulfonamides (called also sulfa drugs) are bacteriostatic, synthetic antibiotics (chemotherapeutics) derived from the family of azo dyes containing the sulfanilamide group in their structure. They were the rst systematically used antibacterial drugs discovered by Gerhard Domagk in 1935 [1], 6 years after the discovery of penicillin by Alexander Fleming. The clinical use of penicillin was not until 1944, while the rst successful clinical trial of sulfonamides was carried out in 1936 at Queen Charlotte’s Maternity Hospital in London [2,3].