^#.^t51: Uncertainty Factors in the Enantioseparation of Chiral Drugs on Silica Gel Layers

Although silica gel has proved the best-performing thin-layer chromatographic (TLC) stationary phase, its application to direct enantioseparations can occasionally lead to certain striking effects, which will be discussed in this chapter. One source of these striking effects is the microcrystalline structure of silica gel.