chapter  27
4 Pages

2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-O-p- nitrophenoxycarbonyl-α-d-glucopyranose

WithTorben Seitz, Caroline Maierhofer, Daniel Matzner, Valentin Wittmann

Preparation of glycoconjugates is of current interest for the investigation of multivalent carbohydrate-protein interactions, and methods for the stereospecic attachment of sugars to scaffold molecules are highly demanded.1 Glycosyl p-nitrophenyl carbonates are suitable precursors for bioconjugation of carbohydrates because they undergo fast reaction with amines producing glycosyl carbamates with retention of conguration at the anomeric center in virtually theoretical yields.2-6 Glycosyl carbamates also nd application as prodrugs.7