chapter  30
6 Pages

Facile Access to (1→3)-Glucosamine Linkages : Synthesis of Propyl 4,6-Di-O-benzyl-2-deoxy-2-trichloroacetamido-1-thio-β-d-glucopyranoside

Experimental Methods ........................................................................................... 236 General Methods ............................................................................................... 236

Propyl 3,4,6-Tri-O-acetyl-2-deoxy-2-trichloroacetamido-1-thio-β-dglucopyranoside (2) ...................................................................................... 236 Propyl 4,6-Di-O-benzyl-2-deoxy-2-trichloroacetamido-1-thio-β-dglucopyranoside (3) ...................................................................................... 237

Acknowledgments .................................................................................................. 238 References ..............................................................................................................240

cosylation.3-5 However, these protecting groups conformationally lock the resulting pyranoses3 and also render them largely incompatible with acidic and/or basic reaction conditions. Benzyl ethers are regarded as one of the most stable and compatible protecting groups in many reaction conditions.