ABSTRACT
References 614
The pathology of dementia with Lewy bodies (DLB) is of a primary degenerative dementia sharing features of both Alzheimer’s disease (AD) and Parkinson’s disease (PD). The diagnosis of DLB is challenging and requires clinicopathological correlation. There is a variable burden of Alzheimer-type pathology (ATP), together with Lewy bodies (LB) in both cortical and subcortical regions. Neocortical Alzheimer senile plaque formation is equivalent to that found in AD, but neocortical neurofibrillary tangles are variable and often infrequent (Dickson et al., 1989; Kosaka et al., 1988; Perry et al., 1990d). DLB patients with only minimal plaque and paired helical filament (PHF)-tau pathology are referred to as ‘pure DLB’ as opposed to the ‘common form’ in which AD pathology is more prominent.
