ABSTRACT
References 644
Frontotemporal dementia (FTD) is the most common of a group of clinical syndromes, associated with degeneration of the frontal and temporal lobes and non-Alzheimer pathology, and collectively referred to as frontotemporal lobar degeneration (FTLD). Behavioural change dominates the clinical picture of FTD at onset and throughout the disease course. However, cognitive impairments, particularly in executive functions, and qualitative changes in language also occur. The paucity of neurological signs and findings of focal abnormalities in the frontotemporal lobes on neuroimaging contribute to the diagnosis. Recent years have seen improved clinical recognition of the disorder and dramatic advances in understanding of its neurobiology.
