chapter  13
17 Pages

MRSA Prevention and Control /

ByRenae E. Stafford

Methicillin-resistant Staphylococcus aureus (MRSA) accounts for sig-

nificant morbidity and mortality worldwide. In the United States,

S. aureus has been isolated from 14.5% of all health care-associated

infections (HAI) reported by acute care hospitals and other health care

facilities to the National Healthcare Safety Network (NHSN) over a

recent 22-month period (1). Over 50% of the staphylococcal infections

that were device related and 49.2% of the surgical site infections (SSIs)

had methicillin-resistant organisms isolated. Central line-associated

bloodstream infections (CLABSI) are the most commonly reported HAIs.

The overall proportion of S. aureus CLABSI in ICUs has increased

between 1997 and 2007 by 25.8% (2). Similar data are reported in Europe

where methicillin resistance was found between 2.2% and 92% of isolates

from ICU S. aureus HAIs (3). Even higher resistance rates have been

identified in a worldwide surveillance system (4).