The medical applications of rimabotulinumtoxinB are not limited to motor neurons, and this toxin can enter many types of neurons in the central nervous system. A major focus has been to identify the receptors and pathways for rimabotulinumtoxinB recognition and entry into neurons. Research done by Dong et al. has established synaptotagmins (Syts) I and II function as protein receptors for rimabotulinumtoxinB utilizing Syt I and II knockout mice ( 53 ). Additionally the same group established that mice lacking gangliosides are less sensitive to rimabotulinumtoxinB entry, supporting the theory that gangliosides act as a coreceptor with Syt I and II for rimabotulinumtoxinB entry into neurons ( 53 ).