ABSTRACT
This chapter focuses on the recent development of multimodal strategies intended to increase the pool of patients with colorectal liver metastases (CRLMs) for whom curative treatment may be possible. These strategies include improved preoperative staging, new standards for surgical resection, novel surgical strategies, the application of modern systemic chemotherapy in the neoadjuvant setting, an emerging role for ablative therapies, greater emphasis on the collaborative, multidisciplinary management of this disease, and most recently, the question of whether to resect the liver disease before the primary bowel tumor. It is now clear that an aggressive multidisciplinary approach to the management of this problem can result in one-third of these patients now being considered for treatment that even if not achieving complete cure, offers significant long-term survival.
