chapter  12
9 Pages

Protein Kinase C Inhibitory Phenylpropanoid Glycosides from Polygonum Species

ByAlbert T. Sneden

Members of the Polygonum genus of plants (family Polygonaceae) are distributed throughout the world and have found use as herbs and medicinal plants.1-3 Extracts of various Polygonum species have shown significant biological activity in several different assays,4-9 prompting investigation of these plants for biologically active natural products. Flavonoids and chalcones have been isolated from several Polygonum species, and some of these show antioxidative activity.10-12 5,7-Dihydroxychromone, isolated from P. persicaria and P. lapathifolium, was found to exhibit antigermination activity.13,14 Warburganal and related drimane-type sesquiterpenes have been isolated from P. hydropiper,15,16 and some of these sesquiterpenes show cytotoxic, antibiotic, and molluscicidal properties. Emodin, a fairly common anthraquinone, has been isolated from P. cuspidatum and shown to inhibit protein tyrosine kinase.17 A stilbene and several stilbene glucosides also have been isolated from P. cuspidatum, and these compounds were found to inhibit both protein tyrosine kinase and protein kinase C (PKC).18 Anthraquinone glucosides which inhibit plant growth have been isolated from P. sachalinense,19 and xanthone and stilbene glucosides have been isolated from P. multiflorum.20 A lignan glucoside has recently been isolated from P. aviculare.21