chapter  5
30 Pages

Chemiluminescent N-Sulfonylacridinium-9-Carboxamides and Their Application in Clinical Assays

The medical diagnostic industry has been both innovator and recipient of products born of modern biotechnology. With contributions from fields as far ranging as synthetic and physical chemistry, immunology, molecular biology, engineering, material and computer science, the industry has delivered powerful tools to diagnose rapidly, and economically, a variety of maladies and to monitor therapies to combat those conditions. The use of immunoassay, and most recently, nucleic acid hybridization assay technologies has been crucial to the

specificity

of these tools, while luminescent detection has provided the required

sensitivity

and

economy

. This chapter details the state of the art of medical diagnostics technology at Abbott Laboratories (Abbott Park, IL), with particular emphasis on the development of a new class of luminescent labels: the

N

-sulfonylacridinium-9carboxamides and their use on the Abbott Laboratories Prism

and Architect

platforms.