ABSTRACT

I. Introduction 41

II. Single Photon Emission Computed Tomography 43

III. Positron Emission Tomography 46

IV. Combined Systems 54

V. Conclusions 55

References 55

I. Introduction

The ever increasing popularity of small animal imaging with radio-tracers has

been made possible by recent technological progress in image resolution and

machine sensitivity (1). The ability to trace the spatial and temporal evolution

and distribution of radio-labeled molecules in appropriate animal models offers

researchers the opportunity to study disease progression, tumor growth, gene

expression, and pharmacokinetics of new drugs in new and valuable ways.