ABSTRACT

I. Introduction 399

II. In Vitro Studies 400

A. Influence of Surfactant on Bacterial Growth 400

B. Influence of Surfactant on Leucocyte Function 405

III. Animal Studies 407

IV. Clinical Studies 409

V. Summary and Perspectives 414

VI. Conclusion 416

Acknowledgments 417

References 417

I. Introduction

During the last decade, surfactant administration has become standard for treat-

ment of premature neonates with severe respiratory distress syndrome (RDS).

Randomized controlled trials and meta-analyses clearly demonstrate improved

gas exchange following surfactant instillation as well as significantly reduced

neonatal morbidity and mortality (1).