ABSTRACT

I. Introduction 88

II. Collectins and Related Proteins 89

III. Tissue Distribution of SP-A and SP-D 91

IV. Potential Functions of SP-A and SP-D 91

V. Structure of SP-A and SP-D 91

VI. Ligands for SP-A and SP-D 93

A. Lipid Ligands for SP-A and SP-D 93

SP-A and Lipids 93

SP-D and Lipids 95

B. Saccharide Ligands for Collectins 96

Saccharide Ligands and SP-A 96

Saccharide Ligands and SP-D 97

VII. Cells and Receptors 99

A. Cells 99

Type II Cells 99

Alveolar Macrophages 100

Polymorphonuclear Leukocyte 101

Dendritic Cells 101

Eosinophils, Basophils, and Mast Cells 101

Lymphocytes 102

Current affiliation: Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.