chapter  10
32 Pages

Analytical Characterization of Synthetic Organic Libraries Nikolai Sepetov and Olga Issakova

A. General Strategy of Analytical Characterization of Combinatorial Libraries..............................................................239 1. Determination of Amount of Synthesized Compound,

Usually by Weighing ............................................................239 B. Requirements for Analytical Techniques Used in

Combinatorial Chemistry............................................................241 C. Analytical Techniques Used in the Early Stages of

Combinatorial Library Development..........................................242 1. Nuclear Magnetic Resonance (NMR)..................................243 2. Infrared (IR) Spectroscopy...................................................244 3. Mass Spectrometry (MS)......................................................244

D. High-Throughput Analytical Techniques Used for Characterization of Combinatorial Libraries..............................245 1. Confirmation of Structure....................................................245 2. Purity Assessment.................................................................246 3. Quantification.......................................................................246