Combinatorial Chemistry: From Split-Mix to Discrete A´rpa´d Furka

I. Introduction .......................................................................................... 8 II. The Split-Mix Synthesis ........................................................................ 9

A. Features of the Synthesis ..............................................................11 1. Formation of All Possible Sequences.....................................11 2. Efficiency of the Synthesis......................................................12 3. Formation of Compounds in One-to-One Molar Ratio ........13 4. Individual Compounds on Beads ...........................................13 5. Applicability of the Split-Mix Procedure for the

Synthesis of ‘‘Organic’’ Libraries ...........................................15 6. The Liquid Phase Split-Mix Synthesis ...................................15