chapter  4
20 Pages

Design of Protease Inhibitors by Computer-Assisted Combinatorial Chemistry

ByVladimir Frecer, Enrico Burello, Stanislav Miertus

I. Introduction ..........................................................................................55 II. Combinatorial Design of Peptidomimetic Inhibitors of HIV PR ........57

A. Selection of Fragments..................................................................58 B. Selection of Analogs .....................................................................60 C. Structure-Based Library Targeting ...............................................60 D. QSAR Analysis .............................................................................63