chapter  28
10 Pages

Gene Therapy for Ventilator-Induced Lung Injury

WithGo€khan M. Mutlu, Yochai Adir, and Phillip Factor

The revolution of gene transfer as an experimental tool and therapy has

created a new potential for the delivery of genetic pharmaceuticals that alter cell physiology in previously unimaginable ways. The accessibility of the

airspace compartment and the availability of vehicles that efficiently trans-

duce epithelial cells offer the possibility of gene therapy to modulate the

pathophysiology of acute lung injury (ALI). It is reasonable to speculate

that some of the genetic therapies being proposed for ALI might be

applicable to ventilator-induced lung injury (VILI). This review includes

the summaries of potential genetic therapies for ALI, which may be appli-

cable for VILI.