chapter  18
28 Pages


WithFrank A. Witzmann, Mu Wang

Proteomics continues to grow in relevance and technical complexity as its importance in the investigation and understanding of protein expression in disease and drug development is recognized. Advances in proteomics have been supported by the continued expansion and availability of pharmacologically relevant genome information and driven by numerous and diverse technological and bioinformatic developments that underscore the complexity of the proteome. This chapter addresses some of the various technologies included in proteomic approaches, and provides salient examples where these technologies have been applied to pharmacology and/or the process of drug development.