chapter  1
12 Pages

Introduction

WithWerner Kalow

The occurrence of genetic influences upon one or other drug response was predicted by Sir Archibald Garrot in his 1931 book Inborn Factors in Diseases (1), and by J.B.S. Haldane in 1949 in an article entitled ‘‘Disease and Evolution’’ (2). Pharmacogenetics, as we know it today, arose as a new scientific entity in the late 1950s as a marriage of the older sciences of Pharmacology and Genetics.