chapter  3
20 Pages


WithGeorgios Panagiotidis, Leif Bertilsson

The interindividual variation in the effect of drug treatment is pronounced. A major part of this is due to variation in drug metabolism, but also due to variation in drug targets such as receptors and transporters, which is evident from other chapters in this second edition of Pharmacogenomics. The rate of drug metabolism is regulated by environmental factors such as food intake and smoking habits, but genetic factors are also of utmost importance.