chapter  6
50 Pages

Introduction: Enzyme Induction in Context

WithAllan B. Okey

It has been evident for several decades that individuals differ markedly, one from the other, in their ability to metabolize drugs and other foreign chemicals (collectively termed ‘‘xenobiotics’’). As described elsewhere in this volume, phenotypic variation in drug metabolism and drug response can have profound clinical implications (1-3). Hence it is important to decipher the mechanisms responsible for interindividual variation.