Th e limitations of mobile computing environments (MCEs) for teleteaching and clinical medicine are discussed in this chapter. We examine the diﬀ erent mechanisms for adaptations that are critical for performance for mobile telemedicine. Our applications and implementation fall under the domain of mobile information access to a centralized server. Many algorithms are built in-house and involve interacting, annotating, constructing, and analyzing diﬀ erent kinds of information, medical images, and multidimensional, multimedia database and video streaming applications. We examine strategies that may enable these applications to continue working seamlessly in any mobile computing environment.