chapter  13
14 Pages

Neurological complications of malignant melanoma

ByMaciej M. Mrugala, John W. Henson

INTRODUCTION Of the three major types of skin cancer-basal cell carcinoma, squamous cell carcinoma, and melanoma-only melanoma typically involves central nervous system (CNS). Skin cancer, particularly melanoma, can occasionally be detected early in its development, at a time when therapy can be curative. About 85% of patients with new diagnosis of cutaneous melanoma present with clinically localized disease (1). However, in many cases, lack of appropriate screening leads to delayed diagnosis and results in poorer outcomes. In instances when initial therapy is not curative malignant melanoma can commonly metastasize and produce neurological complications.