ABSTRACT
Although CCC eliminates various complications arising
from the use of solid support, it was necessary to solve the
challenging problem of how to permanently retain the
stationary phase in the separation column while the mobile
phase is continuously flowing. CCC now uses a variety of
column geometries, mostly combined with simple rotation
or planetary motion, to provide a suitable force field to
retain the stationary phase in the column while inducing
mixing of the two phases to promote the partition process.
All the existing CCC schemes have derived from two
basic CCC types, both using a coiled column: the hydrostatic
and hydrodynamic equilibrium systems (Ito, 1981a) (Fig. 1).
