Modeling Local and Global Calcium Signals Using Reaction-Diffusion Equations

Diffusion Coefficient ...........................................................59 3.3 Modeling Calcium Domains and Localized Calcium Elevations..................60

3.3.1 Numerical Solution of the Full Equations .........................................60 3.3.1.1 Geometry of Simulation and Initial and

Boundary Conditions...........................................................60 3.3.1.2 A Finite Difference Method for Solving the

Full Equations......................................................................61 3.3.1.3 A Representative Simulation of a Localized

Ca

Elevation .....................................................................63 3.3.2 Estimates of Domain Calcium ...........................................................63