chapter  21
26 Pages

Correlations between Apoptosis and HIV Disease Progression

Introduction ....................................................................................................................................355 Rates of HIV Disease Progression ................................................................................................355 Viral and Host Factors That Influence Disease Progression.........................................................356 Evidence for an Influence of Apoptosis in Disease Progression in Lentivirus Infection ............358 Links between Factors Implicated in Disease Progression and Apoptosis ..................................359 Analysis of Apoptosis in Patient Cohorts with Defined Rates of Disease Progression...............361 Impact of Antiretroviral Therapy on Levels of Lymphocyte Apoptosis.......................................363 Discordant Responses to Antiretroviral Therapy ..........................................................................369 Conclusions ....................................................................................................................................369 Acknowledgments ..........................................................................................................................370 References ......................................................................................................................................370

Multiple studies have examined apoptosis in CD4 T cells infected with human immunodeficiency virus (HIV)